Inter Milan beat SPAL 2-1 on Sunday to capitalise on Juventus being held 2-2 by Sassuolo at home and take command of the Serie A standings.
Antonio Conte's men have 37 points from 14 games, one point more than Juve, who are aiming for a ninth consecutive league title this season. Lazio thumped Udinese 3-0 in Rome and are six points behind Juve in third place.
Fourth-placed AS Roma won 3-1 at Hellas Verona.
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