Italian-Canadian team find cause of incurable brain cancer
Identify proteins that spawn deadly, aggressive glioblastoma03 February, 18:27
Glioblastoma currently cannot be stopped by chemotherapy or radiation therapy.
The two proteins could become a promising new target for future therapies, because they act on a specific group of cells in which glioblastoma tumors begin, making up the first nucleus of the tumor, researchers explained.
The proteins enable regrowth of tumors in the target cells and staminal tumour cells, explaining the high rate of cancer reoccurrence after surgery, chemotherapy and radiotherapy, researchers added.
The discovery was carried out by laboratories at McGill University in Montreal, Canada, with the collaboration of Treviso Hospital, the Naples Institute of Genetics and Biophysics, and the Hotchkiss Brain Institute of the University of Calgary in Canada. The article was published in the online scientific journal Nature Communications.